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Polycystic Ovary Syndrome (PCOS) page 2

Yasmin is another hormonal contraception that contains ethinylestradiol (synthetic form of oestrogen) and drospirenone (synthetic form of progesterone). This preparation is taken exactly the same as the pill.

Metformin is a type of drug known as insulin-sensitising agent which increases the sensitivity of the tissues to insulin, reduces insulin levels in the blood stream and indirectly reduces excess androgen levels. A small number of patients taking Metformin, will discontinue treatment complaining of abdominal cramps, nausea and other gastrointestinal side effects. To avoid this it is recommended to take Metformin always at the time of the main meals.

Other anti-androgen treatments
The diuretic drug Spironolactone has anti-androgen properties. It is useful in women unable to take the COC or
Metformin but it should not be taken if trying to conceive. Side effects may include gastro-intestinal disturbance and frequent periods. Finesteride is a powerful anti-androgen usually used to treat male-pattern baldness and overgrowth of the prostate in men. Although the manufacturer does not license it for use in PCOS, it is used in specialist clinics. It is particularly useful in resistant cases with good results and has few side effects. Finesteride should not be taken if trying to conceive.

Topical preparations
Eflornithine HCl Cream (Vaniqa®) is an effective non-hormonal approach to helping women with increased facial hair.
It works directly to slow hair growth by inhibiting the enzyme ornithine decarboxylase (ODC). When this enzyme is blocked metabolic activity in the hair follicle decreases and hair growth is slowed down. Vaniqa® does not remove hair therefore it needs to be used in combination with a removal method. The studies so far have looked at facial and neck hair only, so Vaniqa® is not indicated for body use.

Cosmetic treatment
Cosmetic treatment can be used in addition to or as an alternative to medical drug treatments for excessive hair growth. Alternatives include plucking, shaving, waxing, electrolysis and laser treatments. All improve symptoms.

Treatments to improve fertility
Lack of ovulation is treated initially with up to six cycles of clomiphene citrate (Clomid®). This acts by blocking the
oestrogen receptors, which in turn increases the levels of follicle stimulating hormone (FSH). FSH promotes follicle
recruitment and development within the ovary. The first cycle of treatment with clomiphene should be monitored with ultrasound scan to confirm follicular response to treatment and to reduce the risk of multiple pregnancy (10%). If there is an over response to the treatment and more than 2 follicles are produced the treatment cycle should be abandoned.
Clomiphene should not normally be used for more than 9-12 cycles because of the very limited benefits which have to be balanced against the small risk of ovarian cancer with prolonged exposure. Clomiphene should also not be used in women who have normal regular ovulatory periods as it does improve outcomes.

Some women with PCOS are resistant to treatment with clomiphene. In these cases alternatives include: ovarian drilling which involves making four small holes in the ovary using a needle that carries electricity (diathermy) performed at the time of laparoscopy (keyhole surgery), gonadotrophins (FSH/LH) injections alone or in an assisted conception programme (intrauterine insemination — IUI or in vitro fertilisation — IVF).

Ovulation induction with gonadotrophins should be carried out in a specialist fertility centre. Investigations on behalf of both partners to exclude other co-existing causes of infertility should be considered before starting treatment.